Heritability in the Efficiency of Nonsense-Mediated mRNA Decay in Humans
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چکیده
منابع مشابه
Heritability in the Efficiency of Nonsense-Mediated mRNA Decay in Humans
BACKGROUND In eukaryotes mRNA transcripts of protein-coding genes in which an intron has been retained in the coding region normally result in premature stop codons and are therefore degraded through the nonsense-mediated mRNA decay (NMD) pathway. There is evidence in the form of selective pressure for in-frame stop codons in introns and a depletion of length three introns that this is an impor...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0011657